Name | Ibandronate Sodium Anhydrous |
Synonyms | Bondronat Ibandronate sodium Ibandronic Acid Sodium Salt Ibandronate sodiuM Bondronat Ibandronate Sodium Anhydrous Ibandronate Sodium (anhydrous) (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid monosodium salt sodium hydrogen {1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl}phosphonate Bondronat, (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium Bondronat, (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium sodium [1-hydroxy-1-(hydroxy-oxido-phosphoryl)-3-(methyl-pentyl-amino) propyl]phosphonic acid sodium [1-hydroxy-1-(hydroxy-oxido-phosphoryl)-3-(methyl-pentyl-amino) propyl]phosphonic acid (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid monosodium salt |
CAS | 138844-81-2 |
EINECS | 682-157-0 |
InChI | InChI=1/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1 |
InChIKey | LXLBEOAZMZAZND-UHFFFAOYSA-M |
Molecular Formula | C9H24NNaO7P2 |
Molar Mass | 343.23 |
Boling Point | 587.8°C at 760 mmHg |
Flash Point | 309.3°C |
Solubility | H2O: >10mg/mL |
Vapor Presure | 2.88E-16mmHg at 25°C |
Appearance | solid |
Color | white |
Merck | 14,4873 |
Storage Condition | 2-8°C |
WGK Germany | 3 |
RTECS | SZ8563300 |
HS Code | 29319090 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.931 ml | 14.654 ml | 29.307 ml |
5 mM | 0.586 ml | 2.931 ml | 5.861 ml |
10 mM | 0.293 ml | 1.465 ml | 2.931 ml |
5 mM | 0.059 ml | 0.293 ml | 0.586 ml |
overview | ibandronate sodium is clinically applicable to relieve bone metastasis of cancer or hypercalcemia caused by tumor. In addition, clinical trials of ibandronate sodium in the treatment of postmenopausal osteoporosis and osteitis deforming are being carried out abroad, and good results have been obtained. |
pharmacological action | this product is the third generation bisphosphonate bone resorption inhibitor, which mainly inhibits the dissolution and formation of hydroxyapatite by combining with hydroxyapatite in bone, thus producing anti-bone resorption effect. In addition, the anti-bone resorption effect of this product may also be related to directly changing the formation of bone cells or directly inhibiting osteoblast-mediated cytokines. |
biological activity | sodium Ibandronate is a highly active nitrogen-containing diphosphate that can be used for osteoporosis. |